when science meets nature
Public studies on ingredientsAnimal Study, Bacterial, Human In Vitro, Human Study, In Vitro Study.
PUMKIN - Cucurbita maxima
Research & Studies
PUMKIN - Cucurbita maxima
There are 167 good studies at Pumpkin. Here's a selection:
Abstracts with Pumpkin Research:
Pumpkin seed oil and saw palmetto oil may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.
Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia.
Nutr Res Pract. 2009 ;3(4):323-7. Epub 2009 Dec 31. PMID: 20098586
Heeok Hong, Chun-Soo Kim, Sungho Maeng
This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia. For this purpose, a randomized, double-blind, placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8. Subjects received either sweet potato starch (group A, placebo, 320 mg/day), pumpkin seed oil (group B, 320 mg/day), saw palmetto oil (group C, 320 mg/day) or pumpkin seed oil plus saw palmetto oil (group D, each 320 mg/day). International prostate symptom score, quality of life, serum prostate specific antigen, prostate volume and maximal urinary flow rate were measured. In groups B, C and D, the international prostate symptom score were reduced by 3 months. Quality of life score was improved after 6 months in group D, while those of groups B and C were improved after 3 months, compared to the baseline value. Serum prostate specific antigen was reduced only in group D after 3 months, but no difference was observed in prostate volume in all treatment groups. Maximal urinary flow rate were gradually improved in groups B and C, with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil. From these results, it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinically safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.
Article Published Date : Dec 31, 2008
Study Type : Human Study
Substances : Pumpkin : CK(147) : AC(34), Saw Palmetto : CK(152) : AC(23)
Diseases : Prostatic Hyperplasia: Benign : CK(256) : AC(59)
You will find much more in the following links on the Pumpkin:
A flax and pumpkin seed mixture has anti-atherogenic and hepatoprotective effects.
Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic rats.
Food Chem Toxicol. 2008 Dec;46(12):3714-20. Epub 2008 Oct 1. PMID: 18938206
M Makni, H Fetoui, N K Gargouri, El M Garoui, H Jaber, J Makni, T Boudawara, N Zeghal
Animal Physiology Laboratory, Sciences Faculty, UR 08-73, BP 1171, Tunisia.
Flax and pumpkin seeds are a rich source of unsaturated fatty acids, antioxidants and fibers, known to have anti-atherogenic and hepatoprotective activities. These effects were evaluated in Wistar rats fed with 1% cholesterol diet. The study was performed on 30 male rats divided into three groups: a control group (CD), CD-chol group fed diet with 1% cholesterol and MS-chol group fed diet enriched with flax and pumpkin seed mixture. In CD-chol group, total cholesterol TC, triacylglycerol TG in plasma and liver, plasma LDL-C, atherogenic index AI and LDL/HDL ratio significantly increased. In MS-chol group lipid parameters decreased significantly, plasma and liver fatty acid composition showed an increase of PUFAs (ALA and LA), and MUFAs (oleic and eicosaenoic acid) and a decrease of SFA (palmitic and stearic acid). In plasma and liver of MS-chol group, malondialdehyde levels decreased and the efficiency of antioxidant defense system was improved compared to CD-chol group. Liver histological sections showed lipid storage in hepatocytes of CD-chol group and an improvement was noted in MS-chol group. Our results suggested that flax and pumpkin seed mixture had anti-atherogenic and hepatoprotective effects which were probably mediated by unsaturated fatty acids present in seed mixture.
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Substances : Flaxseed : CK(499) : AC(97), Omega-3 Fatty Acids : CK(3849) : AC(463), Pumpkin Seed Oil/Meal : CK(98) : AC(21)
Diseases : Arteriosclerosis : CK(452) : AC(126), High Cholesterol : CK(1774) : AC(271)
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books.
There are 6642 on Pumpkin.
44 Diseases Researched for Pumpkin - Cucurbita maxima :
Prostatic Hyperplasia: Benign524
Anemia: Iron Deficiency110
Diabetes Mellitus: Type 2110
Kidney Failure: Acute110
Lung Cancer: Prevention110
Parasitic Intestinal Diseases24
Prostatic Hyperplasia, Testosterone-Induced24
Acetaminophen (Tylenol) Toxicity12
Chemically-Induced Liver Damage12
Drug Toxicity: Methotrexate12
Hydrogen Peroxide Induced Toxicity11
Lower Urinary Tract Symptoms11
22 Pharmacological Actions Researched for Pumpkin - Cucurbita maxima :
Bcl-2 protein down-regulation15
Superoxide Dismutase Up-regulation12