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 Chicory (Cichorium intybus L.

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Chicory (Cichorium intybus L. 

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Parsley, basil, and chicory extracts offered a hepatic protection against Dex-induced in rats.
Abstract Title:
Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats.
Abstract Source:
J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):65-71. Epub 2016 Jan 27. PMID: 27069727
Abstract Author(s):
Hanan A Soliman, Mohamed A El-Desouky, Walaa G Hozayen, Rasha R Ahmed, Amal K Khaliefa
Article Affiliation:
Hanan A Soliman
AIM: The objective of this study is to investigate the hypoglycemic, hypolipidemic, and hepatoprotective effects of the aqueous extract of parsley, basil, and chicory whole plant in normal and dexamethasone (Dex) rats.
MATERIALS AND METHODS: 50 female albino rats were used in this study and divided into 5 groups (for each 10). Group (1) fed basal diet and maintained as negative control group. Group (2) received Dex in a dose of (0.1 mg/kg b. wt.). Groups 3, 4, and 5 were treated with Dex along with three different plant extracts of parsley, basil, and chicory (2 g/kg b. wt.), (400 mg/kg b. wt.), and (100 mg/kg b. wt.), respectively.
RESULTS: All these groups were treated given three times per week for 8 consecutive weeks. Dex-induced alterations in the levels of serum glucose, triglyceride, cholesterol, low-density lipoprotein-cholesterol levels and cardiovascular indices and serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, liver thiobarbituric acid (TBARS) levels increased, while high-density lipoprotein-cholesterol, total protein, albumin, and liver glutathione (GSH) levels decreased. On the other hand, plant extracts succeeded to modulate these observed abnormalities resulting from Dex as indicated by the reduction of glucose, cholesterol, TBARS, and the pronounced improvement of the investigated biochemical and antioxidant parameters.
CONCLUSIONS: It was concluded that probably, due to its antioxidant property, parsley, basil, and chicory extracts have hepatoprotective effects in Dex-induced in rats.
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Basil : CK(28) : AC(22), Chicory : CK(23) : AC(8), Parsley : CK(42) : AC(27)
Diseases : Hyperglycemia : CK(539) : AC(130)
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective, Hypoglycemic Agents : CK(1446) : AC(342), Hypolipidemic : CK(1288) : AC(265)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)
Problem Substances : Dexamethasone : CK(71) : AC(16)

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Chicory (Cichorium intybus L.
Chicory (Cichorium intybus L.


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There are 798 on Chicory (Cichorium intybus L.. 

In Silico Analysis and Experimental Validation of Active Compounds from Cichorium intybus L. Ameliorating Liver Injury
In Silico Analysis and Experimental Validation of Active Compounds from Cichorium intybus L. Ameliorating Liver Injury

11 Diseases Researched for Chicory:
Chemically-Induced Liver Damage12
Diabetes Mellitus: Type 112
Liver Disease12
Nitrosamnine-induced Toxicity12
Weight Probems: Appetite12
10 Pharmacological Actions Researched for Chicory:
Gastrointestinal Agents110
Hypoglycemic Agents24
Bone Density Conservation Agents12
Glucagon Like peptide 1 (GLP-1) Up-regulation12

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